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Absence of electrocardiographic findings and improved function with once-daily tiotropium in patients with chronic obstructive pulmonary disease.

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Patients were eligible for assignment to either the TALC study or the BASALT study if at week 4 they had at least 75% adherence to the run-in protocol (as shown by peak flow, diary card, and study medications), an FEV 1 of more than 40% of the predicted value, and no need for additional asthma medications.

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